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Targeted Allele Detail
Symbol: Prg4tm1Mawa
Name: proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein); targeted mutation 1, Matthew Warman
MGI ID: MGI:3513195
Synonyms: Prg4-
Gene: Prg4  Location: Chr1:150449816-150466165 bp, - strand  Genetic Position: Chr1, 63.84 cM, cytoband G
Prg4tm1Mawa/Prg4tm1Mawa mice develop joint disease with increasing age

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:96756
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe targeting construct was designed to create a Prg4-B-gal fusion protein by substituting lacZ for exon 6. Northern blot and in situ hybridization, however, detected no transcript in livers of mutant mice. RT-PCR of synovial and liver mRNA showed aberrant mRNA splicing from the allele which was thought to create a nonsense mediated mRNA decay. (J:96756)
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prg4 Mutation:  6 strains or lines available
Original:  J:96756 Rhee DK, et al., The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth. J Clin Invest. 2005 Mar;115(3):622-31
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.0
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