Klk1^tm1Pmtn
Targeted Allele Detail

Summary

• Symbol: Klk1^tm1Pmtn
• Name: kallikrein 1; targeted mutation 1, Pierre Meneton
• MGI ID: MGI:3513115
• Synonyms: TK^-
• Gene: Klk1 Location: Chr7:43874784-43879042 bp, + strand Genetic Position: Chr7, 28.74 cM
• Alliance: Klk1^tm1Pmtn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67868
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced a 100 bp region in exon 4. Northern blot analysis showed the absence of transcript in mutant kidneys, colon and pancreas. (J:67868)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klk1 Mutation: 22 strains or lines available

References

• Original: J:67868 Meneton P, et al., Cardiovascular abnormalities with normal blood pressure in tissue kallikrein-deficient mice. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2634-9
• All: 17 reference(s)