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Tgfb1tm1Jmu
Targeted Allele Detail
Nomenclature
Symbol: Tgfb1tm1Jmu
Name: transforming growth factor, beta 1; targeted mutation 1, John Munger
MGI ID: MGI:3513111
Synonyms: Tgfb1RGE
Gene: Tgfb1  Location: Chr7:25687002-25705077 bp, + strand  Genetic Position: Chr7, 13.98 cM
Tgfb1tm1Jmu/Tgfb1tm1Jmu mice develop fatal multiorgan inflammation

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:120085
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence, Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance cassette was inserted in the intron between exons 5 and 6. In exon 5, a mutation was introduced that changes a D codon to an E codon (D246E); this mutates the RGD integrin binding site in the propeptide to RGE. (J:120085)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tgfb1 Mutation:  23 strains or lines available
References
Original:  J:120085 Yang Z, et al., Absence of integrin-mediated TGFbeta1 activation in vivo recapitulates the phenotype of TGFbeta1-null mice. J Cell Biol. 2007 Mar 12;176(6):787-93
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory