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Slc12a3tm1Ges
Targeted Allele Detail
Summary
Symbol: Slc12a3tm1Ges
Name: solute carrier family 12, member 3; targeted mutation 1, Gary E Shull
MGI ID: MGI:3513101
Synonyms: Ncc-
Gene: Slc12a3  Location: Chr8:95055829-95092842 bp, + strand  Genetic Position: Chr8, 46.46 cM
Alliance: Slc12a3tm1Ges page
Mitochondrial abnormalities in renal distal convoluted tubule cells of Slc12a3tm1Ges/Slc12a3tm1Ges mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:50596
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin gene was inserted into exon 12. Kidneys from mutants demonstrated a lack of transcript by Northern blot analysis. (J:50596)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 8 assay results
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc12a3 Mutation:  40 strains or lines available
References
Original:  J:50596 Schultheis PJ, et al., Phenotype resembling Gitelman's syndrome in mice lacking the apical Na+-Cl- cotransporter of the distal convoluted tubule. J Biol Chem. 1998 Oct 30;273(44):29150-5
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/26/2022
MGI 6.22
The Jackson Laboratory