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Tubb1tm1Shiv
Targeted Allele Detail
Nomenclature
Symbol: Tubb1tm1Shiv
Name: tubulin, beta 1 class VI; targeted mutation 1, Ramesh A Shivdasani
MGI ID: MGI:3513083
Synonyms: Beta1-tubulin-
Gene: Tubb1  Location: Chr2:174450695-174457882 bp, + strand  Genetic Position: Chr2, 97.95 cM, cytoband H
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94498
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 3, which encodes amino acids 56-451, was replaced with a PGK-neo cassette. Immunoblot of mutant megakaryocytes confirmed a lack of protein. (J:94498)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tubb1 Mutation:  18 strains or lines available
References
Original:  J:94498 Schwer HD, et al., A lineage-restricted and divergent beta-tubulin isoform is essential for the biogenesis, structure and function of blood platelets. Curr Biol. 2001 Apr 17;11(8):579-86
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory