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Targeted Allele Detail
Symbol: Crhbptm1Afs
Name: corticotropin releasing hormone binding protein; targeted mutation 1, Audrey F Seasholtz
MGI ID: MGI:3513042
Gene: Crhbp  Location: Chr13:95431376-95444831 bp, - strand  Genetic Position: Chr13, 49.5 cM
Germline Transmission:  Earliest citation of germline transmission: J:57963
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe translated portion of exon 1 and all of exons 2-5 were replaced with a PGK-neomycin resistance cassette. In situ hybridization confirmed the absence of transcripts in the cerebral cortex. (J:57963)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Crhbp Mutation:  11 strains or lines available
Original:  J:57963 Karolyi IJ, et al., Altered anxiety and weight gain in corticotropin-releasing hormone-binding protein-deficient mice. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11595-600
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
The Jackson Laboratory