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Prdm9repro7
Chemically induced Allele Detail
Nomenclature
Symbol: Prdm9repro7
Name: PR domain containing 9; reproductive mutant 7, JAX Reproductive Mutagenesis Program
MGI ID: MGI:3512904
Synonyms: G1-419-29
Gene: Prdm9  Location: Chr17:15543079-15564354 bp, - strand  Genetic Position: Chr17, 8.95 cM
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsThis ENU induced mutant has a G to A transition at Chromosome 17 position 15,682,049 (build 37) which causes a change in amino acid 478 from glutamine to a premature stop codon. Mutant germ cells produce a truncated protein detected by an antibody that detects the N-terminal domains. (J:222308, J:250814)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prdm9 Mutation:  6 strains or lines available
Notes
Males and females are infertile: very low testis weight, no epididymal sperm are recovered; in females, no oocytes are recovered. Histological analysis shows arrest of spermatogenesis during mid-pachytene stage of meiotic prophase, some seminiferous tubules are greatly depleted of germ cells.
References
Original:  J:92463 JAX Reproductive Mutagenesis Program, Heritable mouse mutants from The Jackson Laboratory Reproductive Genomics Mutagenesis Program. MGI Direct Data Submission. 2004-7;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory