About   Help   FAQ
Lgr5tm1Ah
Targeted Allele Detail
Summary
Symbol: Lgr5tm1Ah
Name: leucine rich repeat containing G protein coupled receptor 5; targeted mutation 1, Aaron Hsueh
MGI ID: MGI:3512420
Synonyms: LGR5-, Lgr5-lacZ, Lgr5tm1Lex
Gene: Lgr5  Location: Chr10:115286219-115423685 bp, - strand  Genetic Position: Chr10, 63.51 cM
Alliance: Lgr5tm1Ah page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94196
Parent Cell Line:  Lex-1 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 18, encoding the seven-transmembrane region plus the C-terminal tail, was replaced with an IRES-lacZ-neo cassette via homologous recombination. (J:94196, J:127123)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Mice Carrying this Mutation: 130 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lgr5 Mutation:  57 strains or lines available
References
Original:  J:94196 Morita H, et al., Neonatal lethality of LGR5 null mice is associated with ankyloglossia and gastrointestinal distension. Mol Cell Biol. 2004 Nov;24(22):9736-43
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory