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Targeted Allele Detail
Symbol: Birc6tm1Sjen
Name: baculoviral IAP repeat-containing 6; targeted mutation 1, Stefan Jentsch
MGI ID: MGI:3512417
Synonyms: BRUCE-
Gene: Birc6  Location: Chr17:74528295-74703356 bp, + strand  Genetic Position: Chr17, 45.64 cM, cytoband E3
Germline Transmission:  Earliest citation of germline transmission: J:94169
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance gene replaced exon 5 and a stop codon introduced into exon 4, thereby eliminating essential portions of the BIR domain. Immunoblot of mutants indicated successful recombination by a lack of protein. (J:94169)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Birc6 Mutation:  158 strains or lines available
Original:  J:94169 Lotz K, et al., BRUCE, a giant E2/E3 ubiquitin ligase and inhibitor of apoptosis protein of the trans-Golgi network, is required for normal placenta development and mouse survival. Mol Cell Biol. 2004 Nov;24(21):9339-50
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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