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Fgf23tm1Blan
Targeted Allele Detail
Nomenclature
Symbol: Fgf23tm1Blan
Name: fibroblast growth factor 23; targeted mutation 1, Beate Lanske
MGI ID: MGI:3512143
Synonyms: Fgf-23-
Gene: Fgf23  Location: Chr6:127072902-127081408 bp, + strand  Genetic Position: Chr6, 61.92 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94041
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1-3 were replaced with lacZ and a neomycin resistance gene. LacZ was cloned in frame downstream of the endogenous initiator methionine. Staining of embryos indicates the mutant gene was expressed in heterozygotes. (J:94041)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 16 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgf23 Mutation:  6 strains or lines available
References
Original:  J:94041 Sitara D, et al., Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice. Matrix Biol. 2004 Nov;23(7):421-32
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory