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Bin1tm2Gcp
Targeted Allele Detail
Nomenclature
Symbol: Bin1tm2Gcp
Name: bridging integrator 1; targeted mutation 2, George C Pendergast
MGI ID: MGI:3512133
Synonyms: Bin1flox
Gene: Bin1  Location: Chr18:32377217-32435736 bp, + strand  Genetic Position: Chr18, 18.01 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:117330
Parent Cell Line:  IT2 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsLoxP sites flank exon 3. The 3' loxP site retained in the floxed ES cell line used to generate chimeric mouse includes a point mutant which reduces the efficiency of in vivo recombination ~50%. (J:117330)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bin1 Mutation:  12 strains or lines available
References
Original:  J:117330 Chang MY, et al., Bin1 ablation in mammary gland delays tissue remodeling and drives cancer progression. Cancer Res. 2007 Jan 1;67(1):100-7
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory