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Targeted Allele Detail
Symbol: Nrp1tm2Ddg
Name: neuropilin 1; targeted mutation 2, David D Ginty
MGI ID: MGI:3512101
Synonyms: Npn-1c, Nrp1fl, Nrp-1flox, Nrp1l/l
Gene: Nrp1  Location: Chr8:128358604-128503363 bp, + strand  Genetic Position: Chr8, 75.78 cM, cytoband E
Germline Transmission:  Earliest citation of germline transmission: J:93799
Parent Cell Line:  GK129 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsAn FRT-flanked neo cassette was inserted upstream of exon 2 and loxP sites were inserted flanking exon 2 via homologous recombination. The neo cassette was removed by mating with mice expressing germline FlpE recombinase. (J:93799)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nrp1 Mutation:  47 strains or lines available
Original:  J:93799 Gu C, et al., Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development. Dev Cell. 2003 Jul;5(1):45-57
All:  68 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory