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Radiation induced Allele Detail
Symbol: Ts(1716)65Dn
Name: trisomy, Chr 16 translocation to Chr 17, Davisson 65
MGI ID: MGI:3512067
Synonyms: T(16C3-4;17A2)65Dn, Ts16, Ts65Dn
Gene: Ts(1716)65Dn  Location: unknown  Genetic Position: Chr16, Syntenic
Cardiovascular abnormalities in Ts(1716)65Dn/0 mice

Show the 1 phenotype image(s) involving this allele.

Strain of Origin:  DBA/2J
Allele Type:    Radiation induced
Mutation:    Translocation
Mutation detailsAbout 15% of the distal end of chromosome 16 (about 13.4 Mb; between Ncam2 (81,624,530 bp; NCBI37/mm9) and Mrpl39 (84,718,526; NCBI37/mm9)) is fused to less than 10% of the centromeric end of chromosome 17 (about 5 to 10 Mb; between RP23-147G23, Synj2 (5,988,977 bp; NCBI37/mm9) and D17Mit58 (10,489,635 bp; NCBI37/mm9)) to form a small translocation chromosome. The translocation breaks mouse Chr 16 just proximal to the amyloid precursor protein ( App ) gene and contains the HSA21-homologous genes from App to the telomere. The translocation chromosome also contains the centromere and a small portion (~5%) of Chr 17. Northern and Western blotting and enzyme activity assays demonstrate that genes on the translocation product are expressed at elevated levels in segmentally trisomic animals. (J:30229, J:71031, J:178871)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 28 assay results
In Structures Affected by this Mutation: 16 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ts(1716)65Dn Mutation:  2 strains or lines available
Original:  J:30229 Davisson MT, et al., Segmental trisomy as a mouse model for Down syndrome. Prog Clin Biol Res. 1993;384:117-33
All:  297 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory