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Targeted Allele Detail
Symbol: Mc4rtm1Lowl
Name: melanocortin 4 receptor; targeted mutation 1, Bradford B Lowell
MGI ID: MGI:3512050
Synonyms: loxTB Mc4r, Mc4rtb
Gene: Mc4r  Location: Chr18:66857715-66860472 bp, - strand  Genetic Position: Chr18, 39.72 cM, cytoband E1
Germline Transmission:  Earliest citation of germline transmission: J:115192
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP flanked PGK-neomycin selection marker inserted in the 5' UTR created a null allele. Cre recombinase deletes the selection marker, restoring normal activity of the allele. Mice fail to respond to MC4R agonist MTII. This is a null allele that can be "reactivated" by cre recombinase. (J:115192)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mc4r Mutation:  0 strains or lines available
Original:  J:115192 Balthasar N, et al., Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell. 2005 Nov 4;123(3):493-505
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
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