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Ddb2tm1Pra
Targeted Allele Detail
Nomenclature
Symbol: Ddb2tm1Pra
Name: damage specific DNA binding protein 2; targeted mutation 1, Pradip Raychaudhuri
MGI ID: MGI:3511965
Synonyms: DDB2-
Gene: Ddb2  Location: Chr2:91211572-91236982 bp, - strand  Genetic Position: Chr2, 50.56 cM, cytoband E1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:95633
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 4 and 5 were replaced with a neomycin selection cassette. Gene expression could not be detected by RT-PCR assay. (J:95633)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ddb2 Mutation:  11 strains or lines available
References
Original:  J:95633 Yoon T, et al., Tumor-prone phenotype of the DDB2-deficient mice. Oncogene. 2005 Jan 13;24(3):469-78
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory