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Tg(TetO-Erbb2)1Lach
Transgene Detail
Nomenclature
Symbol: Tg(TetO-Erbb2)1Lach
Name: transgene insertion 1, Lewis A Chodosh
MGI ID: MGI:3511877
Synonyms: TAN, TetO-NeuNT
Transgene: Tg(TetO-Erbb2)1Lach  Location: unknown  
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Inducible, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(TetO-Erbb2)1Lach expresses 1 gene
 
Mutation detailsThe transgene consists of the tet operator driving expression of a bicistronic transcript encoding activated rat Erbb2 (Neu), having the Val664Leu missense mutation, and firefly luciferase, the latter translated from an internal ribosome binding sequence (IRES) upstream of its coding sequence. In a mouse bitransgenic for this transgene and a tetracycline transactivator transgene, administration of doxycycline reversibly induces expression of Erbb2 and luciferase in tissues where the transactivator is expressed. (J:81083)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:81083 Moody SE, et al., Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis. Cancer Cell. 2002 Dec;2(6):451-61
All:  12 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory