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Rps6kb1tm1Nte
Targeted Allele Detail
Nomenclature
Symbol: Rps6kb1tm1Nte
Name: ribosomal protein S6 kinase, polypeptide 1; targeted mutation 1, Naohiro Terada
MGI ID: MGI:3511860
Synonyms: p70s6k, p85s6k
Gene: Rps6kb1  Location: Chr11:86498871-86544805 bp, - strand  Genetic Position: Chr11, 51.82 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:155912
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette, inserted in opposite orientation, replaced the exon encoding amino acid residues 207-237 in the p70s6k protein. The downstream coding region was also frame shifted. Immunological analysis indicated the absence of activity for both the p70 and the p85 isoforms. (J:47608)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rps6kb1 Mutation:  41 strains or lines available
References
Original:  J:47608 Kawasome H, et al., Targeted disruption of p70(s6k) defines its role in protein synthesis and rapamycin sensitivity. Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5033-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory