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Targeted Allele Detail
Symbol: Ppargtm3(tTA)Yba
Name: peroxisome proliferator activated receptor gamma; targeted mutation 3, Yaacob Barak
MGI ID: MGI:3511359
Synonyms: Ppargtm3Yba, PpargtTA
Gene: Pparg  Location: Chr6:115361221-115490401 bp, + strand  Genetic Position: Chr6, 53.41 cM, cytoband E3-F1
Mild lipodystrophy with modest metabolic anomalies in Ppargtm3(tTA)Yba/Pparg+ mice compared to Ppargtm2(tTA)Yba/Pparg+ mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:125992
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Transactivator)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 2 was replaced with an IRES, tTA and neo cassette. While expression is modest in adipose tissue, it is poor in the liver and placenta. (J:125992)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pparg Mutation:  16 strains or lines available
Original:  J:125992 Kim S, et al., A mouse model of conditional lipodystrophy. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16627-32
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory