About   Help   FAQ
Targeted Allele Detail
Symbol: Leprtm1.2Chua
Name: leptin receptor; targeted mutation 1.2, Streamson C Chua, Jr
MGI ID: MGI:3511285
Synonyms: Leprdelta, Leprdelta17
Gene: Lepr  Location: Chr4:101717404-101815352 bp, + strand  Genetic Position: Chr4, 46.96 cM
Obesity in Leprtm1.2Chua/Leprtm1.2Chua mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:94019
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsLeprtm1.1Chua mice crossed with Cre transgenic mice created this allele in which exon 17 is excised. The predicted result is a truncated receptor protein for all isoforms, with a frameshift in the 3' end of exon 16, thus causing a Lepr-B terminal exon consisting of 14 amino acids and a premature stop codon. RT-PCR confirmed the deletion. (J:94019)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lepr Mutation:  75 strains or lines available
Original:  J:94019 McMinn JE, et al., An allelic series for the leptin receptor gene generated by CRE and FLP recombinase. Mamm Genome. 2004 Sep;15(9):677-85
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.11
The Jackson Laboratory