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Targeted Allele Detail
Symbol: Leprtm1.2Chua
Name: leptin receptor; targeted mutation 1.2, Streamson C Chua, Jr
MGI ID: MGI:3511285
Synonyms: Leprdelta, Leprdelta17
Gene: Lepr  Location: Chr4:101717404-101815352 bp, + strand  Genetic Position: Chr4, 46.96 cM
Obesity in Leprtm1.2Chua/Leprtm1.2Chua mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:94019
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsLeprtm1.1Chua mice crossed with Cre transgenic mice created this allele in which exon 17 is excised. The predicted result is a truncated receptor protein for all isoforms, with a frameshift in the 3' end of exon 16, thus causing a Lepr-B terminal exon consisting of 14 amino acids and a premature stop codon. RT-PCR confirmed the deletion. (J:94019)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lepr Mutation:  37 strains or lines available
Original:  J:94019 McMinn JE, et al., An allelic series for the leptin receptor gene generated by CRE and FLP recombinase. Mamm Genome. 2004 Sep;15(9):677-85
All:  7 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
The Jackson Laboratory