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Leprtm1.1Chua
Targeted Allele Detail
Summary
Symbol: Leprtm1.1Chua
Name: leptin receptor; targeted mutation 1.1 Streamson C Chua, Jr
MGI ID: MGI:3511284
Synonyms: Leprflox
Gene: Lepr  Location: Chr4:101574601-101672549 bp, + strand  Genetic Position: Chr4, 46.96 cM
Alliance: Leprtm1.1Chua page
Obesity in Leprtm1Chua/Leprtm1Chua mice (center) and normal weight in Leprtm1.1Chua/Leprtm1.1Chua (left)

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94019
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsLeprtm1Chua mice crossed with FLP transgenic mice created this allele in which exon 17 is flanked with loxP sites. (J:94019)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 1 assay results
In Structures Affected by this Mutation: 10 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lepr Mutation:  121 strains or lines available
References
Original:  J:94019 McMinn JE, et al., An allelic series for the leptin receptor gene generated by CRE and FLP recombinase. Mamm Genome. 2004 Sep;15(9):677-85
All:  72 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory