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Med1tm2Jkr
Targeted Allele Detail
Summary
Symbol: Med1tm2Jkr
Name: mediator complex subunit 1; targeted mutation 2, Janardan K Reddy
MGI ID: MGI:3511276
Synonyms: Med1fl, PBPfl
Gene: Med1  Location: Chr11:98042980-98084119 bp, - strand  Genetic Position: Chr11, 61.75 cM, cytoband D
Alliance: Med1tm2Jkr page
Heart sections of Med1tm2Jkr/Med1tm2Jkr Tg(Myh6-cre)2182Mds/0 heart reveal thinning of ventricular walls and dilation of chambers.

Show the 5 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:94123
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprt1b-m3
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA single loxP site was introduced in intron 7 and a floxed neomycin cassette was placed in intron 10. The neomycin cassette was later deleted by breeding to EIIa-cre mice leaving exons 8, 9, and 10 flanked by loxP sites. (J:94123)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 34 assay results
7 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Med1 Mutation:  83 strains or lines available
References
Original:  J:94123 Jia Y, et al., Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liver. J Biol Chem. 2004 Jun 4;279(23):24427-34
All:  30 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory