Pdgfc^tm1Nagy
Targeted Allele Detail

Summary

• Symbol: Pdgfc^tm1Nagy
• Name: platelet-derived growth factor, C polypeptide; targeted mutation 1, Andras Nagy
• MGI ID: MGI:3510799
• Synonyms: Pdgfc^-
• Gene: Pdgfc Location: Chr3:80943723-81121347 bp, + strand Genetic Position: Chr3, 35.73 cM
• Alliance: Pdgfc^tm1Nagy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93954
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a SA-IRES-BetageopA cassette. Northern blot analysis indicated a lack of transcript in mutants. X-gal staining showed that the inserted cassette was expressed in the pattern expected from the wild-type allele. (J:93954)

Expression

In Mice Carrying this Mutation:	50 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdgfc Mutation: 35 strains or lines available

References

• Original: J:93954 Ding H, et al., A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling. Nat Genet. 2004 Oct;36(10):1111-6
• All: 17 reference(s)