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Tg(Ins2-Irs2)13Mfw
Transgene Detail
Nomenclature
Symbol: Tg(Ins2-Irs2)13Mfw
Name: transgene insertion 13, Morris F White
MGI ID: MGI:3510672
Synonyms: rip13Irs2
Transgene: Tg(Ins2-Irs2)13Mfw  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThis transgene consists of the Irs2 gene with a FLAG tag at the C terminus driven by the rat insulin II promoter. Two transgenes (lines 9 and 13) were analyzed based on expression level. This transgene expressed a high level of Irs2. Overexpression of the transgene was verified by Western blot analysis of islet extracts, immunostaining of pancreas and by an increase in the pancreatic insulin content. (J:94000)
Phenotypes
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:94000 Hennige AM, et al., Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes. J Clin Invest. 2003 Nov;112(10):1521-32
All:  6 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory