About   Help   FAQ
Psen1tm1Lpr
Targeted Allele Detail
Nomenclature
Symbol: Psen1tm1Lpr
Name: presenilin 1; targeted mutation 1, Laurent Pradier
MGI ID: MGI:3510457
Synonyms: PS1KI, Ps1M233T,L235P
Gene: Psen1  Location: Chr12:83688152-83735199 bp, + strand  Genetic Position: Chr12, 38.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:93770
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted
Mutation:    Nucleotide substitutions
 
Mutation detailsTwo point mutations were introduced into exon 7: M233T and L235P, and a neomycin resistance gene inserted into intron 6. Western blot demonstrated a normal levels of protein in mutants. (J:93770)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Psen1 Mutation:  38 strains or lines available
References
Original:  J:93770 Casas C, et al., Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model. Am J Pathol. 2004 Oct;165(4):1289-300
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/09/2018
MGI 6.12
The Jackson Laboratory