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Targeted Allele Detail
Symbol: Dync2li1tm1Aar
Name: dynein cytoplasmic 2 light intermediate chain 1; targeted mutation 1, Amer Ahmed Rana
MGI ID: MGI:3505858
Synonyms: mD2LIC-
Gene: Dync2li1  Location: Chr17:84626496-84655558 bp, + strand  Genetic Position: Chr17, 55.02 cM, cytoband E4
Germline Transmission:  Earliest citation of germline transmission: J:93573
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 2.75 kb fragment containing 500 bp upstream of the predicted transcriptional start site and the first two exons, which include the translation start site and half the P-loop domain, was replaced with a loxP flanked PGK-neo cassette via homologous recombination. Northern blot analysis confirms absence of RNA. (J:93573)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dync2li1 Mutation:  14 strains or lines available
Original:  J:93573 Rana AA, et al., Targeted deletion of the novel cytoplasmic dynein mD2LIC disrupts the embryonic organiser, formation of the body axes and specification of ventral cell fates. Development. 2004 Oct;131(20):4999-5007
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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