Dync2li1^tm1Aar
Targeted Allele Detail

Summary

• Symbol: Dync2li1^tm1Aar
• Name: dynein cytoplasmic 2 light intermediate chain 1; targeted mutation 1, Amer Ahmed Rana
• MGI ID: MGI:3505858
• Synonyms: mD2LIC^-
• Gene: Dync2li1 Location: Chr17:84933924-84963016 bp, + strand Genetic Position: Chr17, 55.02 cM, cytoband E4
• Alliance: Dync2li1^tm1Aar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93573
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 2.75 kb fragment containing 500 bp upstream of the predicted transcriptional start site and the first two exons, which include the translation start site and half the P-loop domain, was replaced with a loxP flanked PGK-neo cassette via homologous recombination. Northern blot analysis confirms absence of RNA. (J:93573)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dync2li1 Mutation: 23 strains or lines available

References

• Original: J:93573 Rana AA, et al., Targeted deletion of the novel cytoplasmic dynein mD2LIC disrupts the embryonic organiser, formation of the body axes and specification of ventral cell fates. Development. 2004 Oct;131(20):4999-5007
• All: 1 reference(s)