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Targeted Allele Detail
Symbol: Ido1tm1Alm
Name: indoleamine 2,3-dioxygenase 1; targeted mutation 1, Andrew L Mellor
MGI ID: MGI:3505776
Synonyms: IDO-, Ido1-, Ido1-KO
Gene: Ido1  Location: Chr8:24584133-24596952 bp, - strand  Genetic Position: Chr8, 12.76 cM
Germline Transmission:  Earliest citation of germline transmission: J:93796
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA Betagal and neomycin cassette replaced exons 3-5, which encode critical portions of the enzyme catalytic site. Also, a translation stop codon was introduced into exon 2. RT-PCR of total epididymis RNA from mutants showed no transcript was present. Western blot of mutant epididymis confirmed a lack of protein. (J:93797)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ido1 Mutation:  19 strains or lines available
Original:  J:93796 Mellor AL, et al., Cutting edge: induced indoleamine 2,3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion. J Immunol. 2003 Aug 15;171(4):1652-5
All:  90 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory