Mcpt1^tm1Hrpm
Targeted Allele Detail

Summary

• Symbol: Mcpt1^tm1Hrpm
• Name: mast cell protease 1; targeted mutation 1, Hugh R P Miller
• MGI ID: MGI:3505765
• Synonyms: mMCP-1^-
• Gene: Mcpt1 Location: Chr14:56255428-56257841 bp, + strand Genetic Position: Chr14, 28.19 cM
• Alliance: Mcpt1^tm1Hrpm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93795
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced a 4.8 kb fragment containing all five exons. RT-PCR, immunohistochemical and Western blot analysis confirmed absence of RNA in jejunum and protein in intestinal mucosal mast cells, the jejunum and ear pinna. (J:93795)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mcpt1 Mutation: 24 strains or lines available

References

• Original: J:93795 Wastling JM, et al., Histochemical and ultrastructural modification of mucosal mast cell granules in parasitized mice lacking the beta-chymase, mouse mast cell protease-1. Am J Pathol. 1998 Aug;153(2):491-504
• All: 5 reference(s)