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Transgene Detail
Symbol: Tg(Pbsn-Cdc37)1Stp
Name: transgene insertion 1, Lilia Stepanova
MGI ID: MGI:3505712
Synonyms: PB-CDC37.1
Transgene: Tg(Pbsn-Cdc37)1Stp  Location: unknown  
Strain of Origin:  (C57BL/6 x DBA/2)F1
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(Pbsn-Cdc37)1Stp expresses 1 gene
Mutation detailsThe transgene contains a rat probasin promoter, a mouse Cdc37 open reading frame, and SV40 Tag splice site/polyadenylation signal sequence. The transgenic insertion site is assumed to be on the Y chromosome as all transgenic mice are male. Transgenic mice overexpress Cdc37 in prostatic epithelia, a tissue where the endogenous Cdc37 gene product is absent or present at low levels. (J:93695)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Original:  J:93695 Stepanova L, et al., Induction of human Cdc37 in prostate cancer correlates with the ability of targeted Cdc37 expression to promote prostatic hyperplasia. Oncogene. 2000 Apr 27;19(18):2186-93
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory