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Transgene Detail
Symbol: Tg(AZIP/F)1Vsn
Name: transgene insertion 1, Charles Vinson
MGI ID: MGI:3497939
Synonyms: A-ZIP/F1, A-ZIP/F-1
Transgene: Tg(AZIP/F)1Vsn  Location: unknown  
Strain of Origin:  FVB/N
Transgene Type:    Transgenic (Dominant negative, Inserted expressed sequence)
Mutation:    Insertion
Mutation detailsA 7.6 kb segment of the Fabp4 enhancer/promoter was used to drive expression of an artificially constructed cDNA encoding a dominant-negative protein to inhibit the DNA binding of both Cebpa and Jun family members. The protein is 104 amino acids long, with an amino-terminal 9 amino acid Flag epitope, a 13 amino acid linker, a 21 amino acid designed acidic amphipathic helix and a 61 amino acid designed leucine zipper (ZIP/F). The transgene also had an SV40 intron and a PolyA signal. (J:50807)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 7 anatomical structures
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Phenotypic Similarity to Human Syndrome: lipoatrophic diabetes (Seip-Berardinelli syndrome) J:50807, J:226956.
Original:  J:50807 Moitra J, et al., Life without white fat: a transgenic mouse. Genes Dev. 1998 Oct 15;12(20):3168-81
All:  33 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
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