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Raf1tm2Bacc
Targeted Allele Detail
Nomenclature
Symbol: Raf1tm2Bacc
Name: v-raf-leukemia viral oncogene 1; targeted mutation 2, Manuela Baccarini
MGI ID: MGI:3497907
Synonyms: c-raf-1flox, Craff
Gene: Raf1  Location: Chr6:115618573-115676635 bp, - strand  Genetic Position: Chr6, 53.62 cM, cytoband C3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:93687
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to flank exon 3 with loxP sites and to insert a floxed neo into intron 2. Transfection with Cre-expressing plasmid removed the neo. (J:93687)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Raf1 Mutation:  82 strains or lines available
References
Original:  J:93687 Jesenberger V, et al., Protective role of Raf-1 in Salmonella-induced macrophage apoptosis. J Exp Med. 2001 Feb 5;193(3):353-64
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory