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Raf1tm2Bacc
Targeted Allele Detail
Summary
Symbol: Raf1tm2Bacc
Name: v-raf-leukemia viral oncogene 1; targeted mutation 2, Manuela Baccarini
MGI ID: MGI:3497907
Synonyms: c-raf-1flox, Craff
Gene: Raf1  Location: Chr6:115595530-115653596 bp, - strand  Genetic Position: Chr6, 53.62 cM, cytoband C3
Alliance: Raf1tm2Bacc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:93687
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to flank exon 3 with loxP sites and to insert a floxed neo into intron 2. Transfection with Cre-expressing plasmid removed the neo. (J:93687)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Raf1tm2Bacc
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Raf1 Mutation:  114 strains or lines available
References
Original:  J:93687 Jesenberger V, et al., Protective role of Raf-1 in Salmonella-induced macrophage apoptosis. J Exp Med. 2001 Feb 5;193(3):353-64
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory