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Irs2tm2Mfw
Targeted Allele Detail
Nomenclature
Symbol: Irs2tm2Mfw
Name: insulin receptor substrate 2; targeted mutation 2, Morris F White
MGI ID: MGI:3497903
Synonyms: fIrs2, Irs2L
Gene: Irs2  Location: Chr8:10986961-11008430 bp, - strand  Genetic Position: Chr8, 5.35 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:93415
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to flank the coding region with loxP sites. Transient expression of a Cre plasmid excised a floxed neo that had be included in the 5' region of the vector. (J:93415)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Irs2 Mutation:  16 strains or lines available
References
Original:  J:93415 Lin X, et al., Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. J Clin Invest. 2004 Nov;114(7):908-16
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory