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Ddit4tm1Fein
Targeted Allele Detail
Nomenclature
Symbol: Ddit4tm1Fein
Name: DNA-damage-inducible transcript 4; targeted mutation 1, Elena Feinstein
MGI ID: MGI:3497720
Synonyms: RTP801-
Gene: Ddit4  Location: Chr10:59949675-59951770 bp, - strand  Genetic Position: Chr10, 29.66 cM, cytoband B3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:93450
Parent Cell Line:  Lex-1 (ES Cell)
Strain of Origin:  129S5/SvEvBrd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsLacZ and a PGK-neo cassette replaced a 212-bp region encompassing exon 2, the first coding exon, via homologous recombination. Northern blot analysis confirmed absence of protein in various tissues. (J:93450)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ddit4 Mutation:  5 strains or lines available
References
Original:  J:93450 Brafman A, et al., Inhibition of oxygen-induced retinopathy in RTP801-deficient mice. Invest Ophthalmol Vis Sci. 2004 Nov;45(10):3796-805
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/03/2020
MGI 6.15
The Jackson Laboratory