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Sncatm1Sud
Targeted Allele Detail
Nomenclature
Symbol: Sncatm1Sud
Name: synuclein, alpha; targeted mutation 1, Thomas C Sudhof
MGI ID: MGI:3487373
Synonyms: alpha-
Gene: Snca  Location: Chr6:60731575-60829855 bp, - strand  Genetic Position: Chr6, 29.15 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:93686
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe first coding exon, encoding residues 1-40, was deleted via homologous recombination. Immunoblotting confirmed the lack of protein in mutant mice brains. (J:93686)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Snca Mutation:  17 strains or lines available
References
Original:  J:93686 Schluter OM, et al., Role of alpha-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice. Neuroscience. 2003;118(4):985-1002
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory