About   Help   FAQ
Targeted Allele Detail
Symbol: Pax3tm1Mrc
Name: paired box 3; targeted mutation 1, Mario R Capecchi
MGI ID: MGI:3487369
Synonyms: Pax3:Fkhr, Pax3:Foxo1, Pax3P3Fm
Gene: Pax3  Location: Chr1:78101267-78197134 bp, - strand  Genetic Position: Chr1, 39.79 cM
Germline Transmission:  Earliest citation of germline transmission: J:93444
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Inserted expressed sequence, Reporter)
Mutation:    Insertion
Mutation detailsA targeting vector was inserted into the 3' region of the gene, resulting in loxP sites flanking exons 8-10 as well as an inserted polyA/stop signal from the C2 gene and exons 2 and 3 of the Foxo1 gene (with an IRES-eYFP cassette in exon 3). Crossing with FLP expressing mice excised an FRT flanked neo that was also inserted downstream. The mutation allowed normal functioning until activation of Cre recombinase. Cre causes the fusion of exons 1-7 of Pax3 to a region of Foxo1 containing exons 2 and 3, as well as 6.5 kb of the UTR and genomic sequence. Simultaneously, an IRES-eYFP marker is expressed. (J:93444)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 28 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pax3 Mutation:  21 strains or lines available
Original:  J:93444 Keller C, et al., Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function. Genes Dev. 2004 Dec 1;18(21):2614-26
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.16
The Jackson Laboratory