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Targeted Allele Detail
Symbol: Dp(16Cbr1-Fam3b)1Rhr
Name: duplication, Chr 16, H R Reeves 1
MGI ID: MGI:3487283
Synonyms: Ts1Rhr
Gene: Dp(16Cbr1-Fam3b)1Rhr  Location: Chr16:93607837-97504936 bp  Genetic Position: Chr16, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:93223
Parent Cell Line:  MC1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted
Mutation:    Duplication
  Dp(16Cbr1-Fam3b)1Rhr involves 69 genes/genome features (Cbr1, Gm22344, Cbr3 ...) View all
Mutation detailsA duplication of a 3.9 Mb region on chromosome 16 was engineered by Cre-mediated recombination between inserted loxP sites located on different chromosomes. This duplicated segment contains mouse orthologs of 33 conserved and minimally conserved genes in the human Down syndrome critical region. (J:93223)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dp(16Cbr1-Fam3b)1Rhr Mutation:  1 strain or line available
Original:  J:93223 Olson LE, et al., A chromosome 21 critical region does not cause specific down syndrome phenotypes. Science. 2004 Oct 22;306(5696):687-90
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory