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Transgene Detail
Symbol: Tg(GFAP-APOE_i3)37Hol
Name: transgene insertion 37, David M Holtzman
MGI ID: MGI:3057188
Synonyms: GFAP-apoE3 line 37, Tg(GFAP-APOE*3)37Hol, Tg(GFAP-APOE3)37Hol
Transgene: Tg(GFAP-APOE_i3)37Hol  Location: unknown  
Strain of Origin:  C57BL/6 and CBA
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(GFAP-APOE_i3)37Hol expresses 1 gene
Mutation detailsThe transgene contains sequence encoding human apolipoprotein E3 isoform under the control of the human glial fibrillary acidic protein (GFAP) promoter. Two lines were created (lines 2 and 37) with line 37 being chosen as the representative line based on submission to the Jax repository. The pattern of expression of the human apolipoprotein E3 isoform (APOE3) transgenic product in these mice follows the endogenous mouse APOE and GFAP expression patterns in the brain. Human APOE3 is immunodetectable in glia and neuropil in developing and adult mutant mice. (J:93487)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:93487 Sun Y, et al., Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins. J Neurosci. 1998 May 1;18(9):3261-72
All:  14 reference(s)

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MGI 6.04
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