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Tg(GFAP-APOE_i2)14Hol
Transgene Detail
Nomenclature
Symbol: Tg(GFAP-APOE_i2)14Hol
Name: transgene insertion 14, David M Holtzman
MGI ID: MGI:3057185
Synonyms: GFAP-apoE2 line14, Tg(GFAP-APOE*2)14Hol, Tg(GFAP-APOE2)14Hol
Transgene: Tg(GFAP-APOE_i2)14Hol  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6 and CBA
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation details
Phenotypes
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Transgenic mice do not express endogenous mouse apolipoprotein E (APOE). The expression pattern of the transgenic human apolipoprotein E2 isoform (APOE2) follows the endogenous mouse APOE and GFAP expression patterns in the brain. Human APOE2 is immunodetectable in glia and neuropil in developing and adult mutant mice. Cultured astrocytes from transgenic mice secrete APOE2 in lipoproteins that are similar in size to high density plasma lipoproteins (HDL). Detergent-soluble APOE2 protein levels in forebrain tissue from hemizygous mice and in adult human cortex tissue are similar.

Mice that are hemizygous or homozygous for the transgenic insert and homozygous for Apoetm1Unc are viable, normal in size, and do not display any gross physical or behavioral abnormalities.

References
Original:  J:93487 Sun Y, et al., Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins. J Neurosci. 1998 May 1;18(9):3261-72
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory