Tg(TCF/Lef1-lacZ)34Efu
Transgene Detail

Summary

• Symbol: Tg(TCF/Lef1-lacZ)34Efu
• Name: transgene insertion 34, Elaine Fuchs
• MGI ID: MGI:3057160
• Synonyms: TCF-betagal, Tg(Fos-lacZ)34Efu, Top-Gal, TOPGAL
• Transgene: Tg(TCF/Lef1-lacZ)34Efu Location: unknown
• Alliance: Tg(TCF/Lef1-lacZ)34Efu page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: The transgene contains the lacZ gene under the control of a promoter consisting of three consensus lymphoid enhancer binding factor 1/transcription factor 3 (LEF/TCF)-binding motifs upstream of a minimal Fos promoter. This allele is responsive to canonical Wnt/beta-catenin signal transduction. (J:55937)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(TCF/Lef1-lacZ)34Efu

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

Notes

Homozygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.

Transgenic mice express beta-galactosidase in the presence of the lymphoid enhancer binding factor 1/transcription factor 3 (LEF1/TCF3) mediated signaling pathway and activated Beta-catenin (CATNB).

Transgenic mice display Beta-galactosidase activity during early embryonic development in a subset of pluripotent embryonic basal cells of the epithelium and dermis of developing hair follicles. Beta-galactosidase activity is not detected in the next stage of hair follicle development, formation of hair germs. At E16.5, transgene activity reappears in hair follicles and is detectable until 18 days after birth.

References

• Original: J:55937 DasGupta R, et al., Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation. Development. 1999 Oct;126(20):4557-68
• All: 201 reference(s)