Tg(DBH-Gal)1923Stei
Transgene Detail
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Symbol: |
Tg(DBH-Gal)1923Stei |
Name: |
transgene insertion 1923, Robert A Steiner |
MGI ID: |
MGI:3057122 |
Synonyms: |
GALANIN-Tg, GalOE, GalOE/D, GALTG |
Transgene: |
Tg(DBH-Gal)1923Stei Location: unknown
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Alliance: |
Tg(DBH-Gal)1923Stei page
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Strain of Origin: |
(SJL x C57BL/6)F1
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(DBH-Gal)1923Stei expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Note |
mouse |
Gal (MGI:95637) |
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Mutation details: The transgene contains a 5.8 Kb sequence of human dopamine beta-hydroxylase promoter and a 4.6 Kb sequence of the mouse galanin gene. In situ hybridization analysis of brain detects a 5-fold increase in galanin mRNA levels in the locus coeruleus region. Radioimmunoassay reveals a 2-fold increase in gene product peptide level in the forebrain. An increase of galanin-like immunoreactive staining and fiber density is also detected.
(J:77625)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:77625 Mazarati AM, et al., Modulation of hippocampal excitability and seizures by galanin. J Neurosci. 2000 Aug 15;20(16):6276-81 |
All: |
14 reference(s) |
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