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Tg(Igk-C/Igk-V125)1Jwt
Transgene Detail
Nomenclature
Symbol: Tg(Igk-C/Igk-V125)1Jwt
Name: transgene insertion 1, James W Thomas
MGI ID: MGI:3057119
Synonyms: VK125, VK125-Ck
Transgene: Tg(Igk-C/Igk-V125)1Jwt  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Igk-C/Igk-V125)1Jwt expresses 1 gene
 
Mutation detailsThe transgene encodes a light chain that, when co-expressed with a transgene encoding the heavy chain with the VDJ of mAB125, binds most mammalian insulins. The source of the immunoglobulin kappa chain VJ sequence in this transgene was the BALB/c IgG1 mouse anti-human insulin monoclonal antibody, mAb125 (from the American Type Culture Collection). (J:91865)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:91865 Hulbert C, et al., B cell specificity contributes to the outcome of diabetes in nonobese diabetic mice. J Immunol. 2001 Nov 15;167(10):5535-8
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory