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Transgene Detail
Symbol: Tg(SMN2)2Hung
Name: transgene insertion 2, Hung Li
MGI ID: MGI:3056903
Synonyms: SMN2+
Transgene: Tg(SMN2)2Hung  Location: unknown  
Strain of Origin:  FVB/N
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(SMN2)2Hung expresses 1 gene
Mutation detailsThe transgene consists of 115kb of sequence from the SMN BAC clone 7C, including the entire human SMN2 coding region and flanking sequence. Five lines were generated. (J:59313)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Five lines were generated.

Hemizygous transgenic mice that are also homozygous for Smn1tm1Hung display:

  • a range of spinal muscular atrophy (SMA)-like pathologies characterized as type 1, type 2, and type 3
    • Type 1 animals do not develop hairy fur, and die before postnatal day 10
    • Type 2 animals exhibit poor activity and variable symptoms, and die at approximately 2-4 weeks
    • Type 3 animals survive to adulthood and are fertile, but have short enlarged tails
  • Transgene copy number correlates with the amount of protein that contains the region encoded by exon 7 and the severity of SMA-like phenotypes in these animals

Original:  J:59313 Hsieh-Li HM, et al., A mouse model for spinal muscular atrophy. Nat Genet. 2000 Jan;24(1):66-70
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory