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Transgene Detail
Symbol: Tg(LCK-NFKBIA)5Dwb
Name: transgene insertion 5, Dean W Ballard
MGI ID: MGI:3056807
Synonyms: IkappaBalpha(deltaN), IkappaNalphadeltaN-Tg, LCK
Transgene: Tg(LCK-NFKBIA)5Dwb  Location: unknown  
Strain of Origin:  C57BL/6 x DBA/2
Transgene Type:    Transgenic (Dominant negative, Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(LCK-NFKBIA)5Dwb expresses 1 gene
Mutation detailsAn amino acid-truncated human NFKBIA gene (coding for amino acids 37-317) fused to a FLAG epitope was placed under the control of a human LCK promoter. The protein encoded by this transgene lacks sequences required for signal-dependent degradation and functions as a constitutive repressor of multiple NK-kappaB pathways. Transgene expression was readily detected in the thymus and spleen as determined by immunoblot analysis. (J:93003)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Original:  J:93003 Boothby MR, et al., Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-kappaB. J Exp Med. 1997 Jun 2;185(11):1897-907
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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