About   Help   FAQ
Tg(LCK-NFKBIA)5Dwb
Transgene Detail
Nomenclature
Symbol: Tg(LCK-NFKBIA)5Dwb
Name: transgene insertion 5, Dean W Ballard
MGI ID: MGI:3056807
Synonyms: IkappaBalpha(deltaN), IkappaNalphadeltaN-Tg, LCK
Transgene: Tg(LCK-NFKBIA)5Dwb  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6 x DBA/2
Transgene
description
Transgene Type:    Transgenic (Dominant negative, Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(LCK-NFKBIA)5Dwb expresses 1 gene
 
Mutation detailsAn amino acid-truncated human NFKBIA gene (coding for amino acids 37-317) fused to a FLAG epitope was placed under the control of a human LCK promoter. The protein encoded by this transgene lacks sequences required for signal-dependent degradation and functions as a constitutive repressor of multiple NK-kappaB pathways. Transgene expression was readily detected in the thymus and spleen as determined by immunoblot analysis. (J:93003)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
References
Original:  J:93003 Boothby MR, et al., Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-kappaB. J Exp Med. 1997 Jun 2;185(11):1897-907
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/18/2020
MGI 6.14
The Jackson Laboratory