About   Help   FAQ
Tg(Tcrb)93Vbo
Transgene Detail
Nomenclature
Symbol: Tg(Tcrb)93Vbo
Name: transgene insertion 93, Harald von Boehmer
MGI ID: MGI:3056727
Synonyms: HYbeta, TCRBbeta8.2, TCRB TG, Vbeta8.2tg
Transgene: Tg(Tcrb)93Vbo  Location: unknown  
Transgene
origin
Strain of Origin:  (CBA/BrA x C57BL/LiA)F2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Tcrb)93Vbo expresses 1 gene
 
Mutation detailsThe transgene contains a rearranged genomic segment derived from the Tcrb locus, and was constructed from B6 (Tcrb-V8.2,Tcrb-D) and BALB/c (Tcrb-J, Tcrb-C) sequences. Over 98% of T cells express the transgenic TCR-beta chain in hemizygous mice. The rearranged beta-chain sequence was isolated from an anti-H-Y, H-2Db-restricted CD8+ T cell clone, B6.2.16. (J:51117, J:93247)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
In transgenic mice, T lymphocytes express the transgene on cell surfaces while the protein products encoded by endogenous Tcrb genes are not expressed. Most homozygous transgenic mice do not survive beyond postnatal week four.
References
Original:  J:93247 Uematsu Y, et al., In transgenic mice the introduced functional T cell receptor beta gene prevents expression of endogenous beta genes. Cell. 1988 Apr 25;52(6):831-41
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2019
MGI 6.14
The Jackson Laboratory