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Tg(H2KmPCC)2939Stoe
Transgene Detail
Nomenclature
Symbol: Tg(H2KmPCC)2939Stoe
Name: transgene insertion 2939, Stephan Oehen
MGI ID: MGI:3056682
Synonyms: mPCC
Transgene: Tg(H2KmPCC)2939Stoe  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6 x SJL
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(H2KmPCC)2939Stoe expresses 1 gene
 
Mutation detailsPigeon cytochrome c was engineered for expression in lymphoid tissues of transgenic mice in two forms. The form of cytochrome c in this construct is expressed as a type II plasma membrane protein (mPCC) by replacing the NH2-terminal mitochondrial targeting sequence with the influenza neuraminidase type II signal anchor. mRNA expression levels are higher in mice carrying this transgene than in mice carrying Tg(H2KePCC)2403. PCC was expressed in thymus, spleen and LPS stimulated B cells as determined by Northern blot. (J:92997)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:92997 Oehen S, et al., Antigen compartmentation and T helper cell tolerance induction. J Exp Med. 1996 Jun 1;183(6):2617-26
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory