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Targeted Allele Detail
Symbol: Krt10tm2Tmm
Name: keratin 10; targeted mutation 2, Thomas M Magin
MGI ID: MGI:3056582
Synonyms: K10-
Gene: Krt10  Location: Chr11:99385254-99389364 bp, - strand  Genetic Position: Chr11, 62.92 cM
Germline Transmission:  Earliest citation of germline transmission: J:93249
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-HPRT minigene replaced 414 bp of the promoter region and exons 1 and 2. Immunofluorescence, Northern blot and Western blot analyses confirmed absence of the protein in all epidermal strata of mutant mice. (J:93249)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Krt10 Mutation:  20 strains or lines available
Original:  J:93249 Reichelt J, et al., Formation of a normal epidermis supported by increased stability of keratins 5 and 14 in keratin 10 null mice. Mol Biol Cell. 2001 Jul;12(6):1557-68
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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