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Targeted Allele Detail
Symbol: Fn1tm1Ksek
Name: fibronectin 1; targeted mutation 1, Kiyotoshi Sekiguchi
MGI ID: MGI:3056581
Synonyms: EDB-, EIIIB-null
Gene: Fn1  Location: Chr1:71585520-71653200 bp, - strand  Genetic Position: Chr1, 36.05 cM, cytoband C1-C5
Germline Transmission:  Earliest citation of germline transmission: J:93250
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsExon EDB (EIIIB) was deleted upon transient expression of Cre recombinase, which excised the floxed sequence containing a neomycin resistance gene and the exon. Immunoblot of mutant MEFs against an anti-EDB antibody indicated lack of protein from this exon. (J:93250)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fn1 Mutation:  86 strains or lines available
Original:  J:93250 Fukuda T, et al., Mice lacking the EDB segment of fibronectin develop normally but exhibit reduced cell growth and fibronectin matrix assembly in vitro. Cancer Res. 2002 Nov 1;62(19):5603-10
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory