Th^tm1(cre)Te
Targeted Allele Detail

Summary

• Symbol: Th^tm1(cre)Te
• Name: tyrosine hydroxylase; targeted mutation 1, Ted Ebendal
• MGI ID: MGI:3056580
• Synonyms: TEb-3, Th^cre, Th^IRES-Cre, Th-IRES-Cre, Th::IRES-Cre
• Gene: Th Location: Chr7:142446516-142453732 bp, - strand Genetic Position: Chr7, 88.06 cM
• Alliance: Th^tm1(cre)Te page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:93194
• Parent Cell Line: GSI-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Th^tm1(cre)Te expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Th (MGI:98735)

• Mutation details: An IRES-cre cassette and FRT-flanked neo was inserted into the 3' UTR. Crossing with FLP deleter mice excised the neo. Immunostaining demonstrated that the inserted sequence did not interfere with endogenous expression and that cre was expressed in mutant mesencephalon and adrenal gland. Cre expression is also detected in oocytes. (J:93194)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Th (mouse) Summary of all recombinase alleles driven by Th. Comparative matrix view of recombinase activities Alliance mouse Th gene page

Disease models

Expression

In Mice Carrying this Mutation:

14 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Th Mutation: 57 strains or lines available

References

• Original: J:93194 Lindeberg J, et al., Transgenic expression of Cre recombinase from the tyrosine hydroxylase locus. Genesis. 2004 Oct;40(2):67
• All: 112 reference(s)