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Targeted Allele Detail
Symbol: Foxp1tm1Eem
Name: forkhead box P1; targeted mutation 1, Edward E Morrisey
MGI ID: MGI:3056542
Synonyms: Foxp4Neo
Gene: Foxp1  Location: Chr6:98925338-99522721 bp, - strand  Genetic Position: Chr6, 45.74 cM, cytoband E1
Germline Transmission:  Earliest citation of germline transmission: J:93182
Parent Cell Line:  SM1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 12, 13, and 14, that encode the forkhead DNA-binding domain, were replaced with a Neo cassette via homologous recombination. RT-PCR and immunohistochemistry confirmed absence of mRNA in embryos and protein in heart tissue. (J:93182)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Foxp1 Mutation:  47 strains or lines available
Original:  J:93182 Wang B, et al., Foxp1 regulates cardiac outflow tract, endocardial cushion morphogenesis and myocyte proliferation and maturation. Development. 2004 Sep;131(18):4477-87
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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