About   Help   FAQ
The MGI survey is now closed.
Thanks for your support!
Targeted Allele Detail
Symbol: Rs1tm1Sie
Name: retinoschisis (X-linked, juvenile) 1 (human); targeted mutation 1, Paul A Sieving
MGI ID: MGI:3056058
Synonyms: RS-1-
Gene: Rs1  Location: ChrX:160768013-160799663 bp, + strand  Genetic Position: ChrX, 73.95 cM
Germline Transmission:  Earliest citation of germline transmission: J:93040
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance gene replaced exon 1, including 9 bp upstream of the ATG, and part of intron 1. Western blot of retinas from mutant mice indicated no protein was present. (J:93040)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rs1 Mutation:  2 strains or lines available
Original:  J:93040 Zeng Y, et al., RS-1 Gene Delivery to an Adult Rs1h Knockout Mouse Model Restores ERG b-Wave with Reversal of the Electronegative Waveform of X-Linked Retinoschisis. Invest Ophthalmol Vis Sci. 2004 Sep;45(9):3279-85
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 5.21
The Jackson Laboratory