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Enahtm1Fbg
Targeted Allele Detail
Summary
Symbol: Enahtm1Fbg
Name: ENAH actin regulator; targeted mutation 1, Frank B Gertler
MGI ID: MGI:3056050
Synonyms: MenaBetageo
Gene: Enah  Location: Chr1:181723949-181847555 bp, - strand  Genetic Position: Chr1, 84.93 cM
Alliance: Enahtm1Fbg page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:53259
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe replacement of exons 2 and 4 with a beta-geo cassette left the beta-geo under the control of the initiator methionine. Western blot showed complete lack of endogenous protein in mutant brains. Beta-galactosidase expression was demonstrated in the developing and adult brains of mutants. (J:53259)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 57 assay results
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Enah Mutation:  208 strains or lines available
References
Original:  J:53259 Lanier LM, et al., Mena is required for neurulation and commissure formation. Neuron. 1999 Feb;22(2):313-25
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory